Traditional,Chinese,medicine,t health Traditional Chinese medicine treat advanced gastric cancer
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As we all know, the adequacy of local control is the key totreat gastric cancer. The incidence rate of the incidence of primary gastriccancer liver metastases is 4% to 14%. Gastric cancer liver metastases is stillincurable, patients with 5-year survival rate is only 10%.Gastric cancer liver metastases, oftenaccompanied with peritoneal dissemination, lymph node metastasis or tumordirect violation of other organs, so few reports about the resection of livermetastases of gastric cancer. Compared with colorectal cancer, the vastmajority of gastric cancer liver metastases often prompts the disease has beenwidely spread. A report shows that in gastric cancer patients with livermetastases, only 1/5 of the patients line liver metastases resection. Thesurvival rate of liver resection is relatively poor, 2/3 of patients withintrahepatic recurrence. Such a high relapse rate in surgery within 2 yearsmeans that there is a potential intrahepatic metastases in hepatectomy.According to pharmaceutical raw materials suppliers,many new drugs such as oxaliplatin, taxane, irinotecan and S-1 and so on for patientswith advanced gastric cancer provide a more effective and safe treatmentoption. Studies have shown that the effective rate of 5-FU + calcium folinate(CF) with oxaliplatin combination chemotherapy is 38% to 54%, overall survival is8 to 11 months, and good security. The effective of taxane treat advancedgastric cancer was 11% to 24%. Another study showed that single-agentirinotecan in the treatment of gastric cancer was 20%. Various chemotherapy containingirinotecan showed a better relieve rate. Whats more, the irinotecanprice ismoderate, can be widelyused.S-1 is a fluorouracil derivative oralanticancer drug, compared with 5-FU has the following advantages: (1) canmaintain a high blood concentration and improve anticancer activity; (2)significantly reduce drugtoxicity; (3) getting drugs convenient. In Japan, S-1 in 1999, has been approved it in thetreatment of advanced gastric cancer. In Japan, more than 80% of the advancedgastric cancer chemotherapy use the S-1, its efficiency up to 44.6%. Clinicaltrials have shown that the effective rate of S-1 for gastric cancer with livermetastasis was 25% to 31%.Recently, a clinical trial conducted byoncologists show that S-1 single-agent efficacy was not inferior to 5-FU alonedrug; irinotecan combined with cisplatin was no better than use 5-FU alone. Analysisshowed that irinotecan can significantly prolonged progression-free survivaland overall survival associated with liver metastasis or lymph node metastasisin patients with irinotecan plus cisplatin. In addition, studies have shownthat the first-line treatment for advanced gastric cancer, S-1 plus cisplatin ismore effective than the S-1 single drug. Therefore, S-1 plus cisplatin hasbecome one of the standard first-line treatment of advanced gastric cancerprogram in Japan.In S-1 combined with docetaxel clinical trials, types and histopathologicaltypes of gastric cancer involving the organ does not affect the efficacy of theprogram, wherein the overall response rate of gastric cancer liver metastaseswas 64.7%.In addition, countries in the treatment ofadvanced gastric cancer chemotherapy are not the same. Such as the United States is often used docetaxel +cisplatin +5- FU, Europe often used epirubicin + cisplatin +5- FU or epirubicin+ oxaliplatin + capecitabine, while South Korea is recommended cisplatin +capecitabine. But the efficacy of the above methods in gastric metastasis hasnot been reported.Source:http://www.cospcn.com
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