Pfizer,admits,that,the,Cox-2,d health Pfizer admits that the Cox-2 drug Bextra is linked to heart

If the vagina is not offering the firm grip to your male partner, he expresses displeasure in lovemaking. You need to tighten the orifice and regain lost elasticity. You can make use of herbal remedies for loose vagina treatment naturally. H The technology behind listening devices has improved dramatically in recent years, giving new hope to those with impairment. While still far from a perfect replacement for the natural ability to hear, these devices give those with a disabili

Pfizer admits that the Cox-2 drug Bextra is linked to heart problems Clinical trials showed heart bypass surgery patients taking Bextra, an anti-inflammatory in the same class as the recently withdrawn drug Vioxx, had a higher risk of stroke and heart attack. It was already known that Bextra can cause a rare, but sometimes fatal, skin disorder called Stevens-Johnson syndrome to note that cases of the condition are being seen more often with Bextra than with other drugs in the same class. Warnings about this have been recently updated. Bextra is approved to treat pain from arthritis and, like Merck & Co.'s Vioxx, is a COX-2 inhibitor. A recent trial showed Vioxx doubled the risk of heart attack and stroke in arthritis patients who took the drug for more than 18 months. This is significant because these patients are already at risk of stroke or heart attack. So a drug like Bextra could be very dangerous if Bextra increases and already higher than normal risk of stroke or heart attack. The Vioxx withdrawal has cast a cloud over the entire class of COX-2 inhibitors, which includes Bextra, Celebrex and an experimental drug from Novartis AG called Prexige. However, Pfizer said that following the Vioxx withdrawal it re-examined its clinical data base of 8,000 patients with rheumatoid arthritis and osteoarthritis and found no increased risk of dangerous heart events in patients taking Bextra for up to a year. The company also found no increased risk in a trial of patients taking Bextra in a general surgery setting. Of course, check the source, as Cox-2 drugs like Bextra account for $6 billion in sales per year! Doctors said it is too early to quantify the potential risk of Bextra or of Pfizer's other COX-2 inhibitor Celebrex as neither have tested for long enough. Pfizer said it is conducting longer term trials in arthritis patients. The coronary bypass trials are ones that Dr. Eric Topol of the Cleveland Clinic Foundation and an early and outspoken critic of Vioxx, said he finds concerning as they show a cluster of heart attacks and strokes. But he said the danger signal does not appear to be as strong as it was with Vioxx. "Celebrex and Bextra do appear safer than Vioxx but whether they are really safe, especially in patients with heart risk, that's an open question," Topol said. Pfizer has updated the label on several occasions since it was approved in 2001 to reflect the risk of Stevens Johnson syndrome, a form of allergic reaction often caused by certain types of drug. Symptoms usually begin as a blistering of the mouth and lips, spreading to the throat, tongue and other parts of the body. The blisters sometimes become so extensive as to be fatal. The company also updated its warning that Bextra can cause a rare, but sometimes fatal, skin disorder called Stevens-Johnson syndrome to note that cases of the condition are being seen more often with Bextra than with other drugs in the same class. Now the label should be updated to include information on stroke and heart attack risks from Bextra. Bextra is approved to treat pain from arthritis and, like Merck & Co.'s Vioxx, is a COX-2 inhibitor. A recent trial showed Vioxx doubled the risk of heart attack and stroke in arthritis patients who took the drug for more than 18 months. The Vioxx withdrawal has cast a cloud over the entire class of COX-2 inhibitors, which includes Bextra, Celebrex and an experimental drug from Novartis AG called Prexige. However, Pfizer said that following the Vioxx withdrawal it re-examined its clinical data base of 8,000 patients with rheumatoid arthritis and osteoarthritis and found no increased risk of dangerous heart events in patients taking Bextra for up to a year. The company also found no increased risk in a trial of patients taking Bextra in a general surgery setting. Again, check the source. Doctors said it is too early to quantify the potential risk of Bextra or of Pfizer's other COX-2 inhibitor Celebrex as neither have tested for long enough. Pfizer said it is conducting longer term trials in arthritis patients. The coronary bypass trials are ones that Dr. Eric Topol of the Cleveland Clinic Foundation and an early and outspoken critic of Vioxx, said he finds concerning as they show a cluster of heart attacks and strokes. But he said the danger signal does not appear to be as strong as it was with Vioxx. "Celebrex and Bextra do appear safer than Vioxx but whether they are really safe, especially in patients with heart risk, that's an open question," Topol said. Pfizer has updated the label on several occasions since it was approved in 2001 to reflect the risk of Stevens Johnson syndrome, a form of allergic reaction often caused by certain types of drug. Symptoms usually begin as a blistering of the mouth and lips, spreading to the throat, tongue and other parts of the body. The blisters sometimes become so extensive as to be fatal. The company also updated its warning that Bextra can cause a rare, but sometimes fatal, skin disorder called Stevens-Johnson syndrome to note that cases of the condition are being seen more often with Bextra than with other drugs in the same class. Bextra is approved to treat pain from arthritis and, like Merck & Co.'s Vioxx, is a COX-2 inhibitor. A recent trial showed Vioxx doubled the risk of heart attack and stroke in arthritis patients who took the drug for more than 18 months. The Vioxx withdrawal has cast a cloud over the entire class of COX-2 inhibitors, which includes Bextra, Celebrex and an experimental drug from Novartis AG called Prexige. However, Pfizer said that following the Vioxx withdrawal it re-examined its clinical data base of 8,000 patients with rheumatoid arthritis and osteoarthritis and found no increased risk of dangerous heart events in patients taking Bextra for up to a year. The company also found no increased risk in a trial of patients taking Bextra in a general surgery setting. Doctors said it is too early to quantify the potential risk of Bextra or of Pfizer's other COX-2 inhibitor Celebrex as neither have tested for long enough. Pfizer said it is conducting longer term trials in arthritis patients. The coronary bypass trials are ones that Dr. Eric Topol of the Cleveland Clinic Foundation and an early and outspoken critic of Vioxx, said he finds concerning as they show a cluster of heart attacks and strokes. But he said the danger signal does not appear to be as strong as it was with Vioxx. "Celebrex and Bextra do appear safer than Vioxx but whether they are really safe, especially in patients with heart risk, that's an open question," Topol said. Pfizer has updated the label on several occasions since it was approved in 2001 to reflect the risk of Stevens Johnson syndrome, a form of allergic reaction often caused by certain types of drug. Symptoms usually begin as a blistering of the mouth and lips, spreading to the throat, tongue and other parts of the body. The blisters sometimes become so extensive as to be fatal. The company also updated its warning that Bextra can cause a rare, but sometimes fatal, skin disorder called Stevens-Johnson syndrome to note that cases of the condition are being seen more often with Bextra than with other drugs in the same class. Bextra is approved to treat pain from arthritis and, like Merck & Co.'s Vioxx, is a COX-2 inhibitor. A recent trial showed Vioxx doubled the risk of heart attack and stroke in arthritis patients who took the drug for more than 18 months. The Vioxx withdrawal has cast a cloud over the entire class of COX-2 inhibitors, which includes Bextra, Celebrex and an experimental drug from Novartis AG called Prexige. However, Pfizer said that following the Vioxx withdrawal it re-examined its clinical data base of 8,000 patients with rheumatoid arthritis and osteoarthritis and found no increased risk of dangerous heart events in patients taking Bextra for up to a year. The company also found no increased risk in a trial of patients taking Bextra in a general surgery setting. Doctors said it is too early to quantify the potential risk of Bextra or of Pfizer's other COX-2 inhibitor Celebrex as neither have tested for long enough. Pfizer said it is conducting longer term trials in arthritis patients. The coronary bypass trials are ones that Dr. Eric Topol of the Cleveland Clinic Foundation and an early and outspoken critic of Vioxx, said he finds concerning as they show a cluster of heart attacks and strokes. But he said the danger signal does not appear to be as strong as it was with Vioxx. "Celebrex and Bextra do appear safer than Vioxx but whether they are really safe, especially in patients with heart risk, that's an open question," Topol said. Pfizer has updated the label on several occasions since it was approved in 2001 to reflect the risk of Stevens Johnson syndrome, a form of allergic reaction often caused by certain types of drug. Symptoms usually begin as a blistering of the mouth and lips, spreading to the throat, tongue and other parts of the body. The blisters sometimes become so extensive as to be fatal. Article Tags: Cox-2 Drug Bextra, Patients Taking Bextra, Sometimes Fatal Skin, Fatal Skin Disorder, Skin Disorder Called, Disorder Called Stevens-johnson, Called Stevens-johnson Syndrome, Being Seen More, Seen More Often, Treat Pain From, Pain From Arthritis, Merck Co's Vioxx, Recent Trial Showed, Trial Showed Vioxx, Showed Vioxx Doubled, Cox-2 Inhibitors Which, Inhibitors Which Includes, Which Includes Bextra, Includes Bextra Celebrex, Experimental Drug From, Drug From Novartis, Called Prexige However, Prexige However Pfizer, However Pfizer Said, Clinical Data Base, Dangerous Heart Events, General Surgery Setting, Pfizer's Other Cox-2, Other Cox-2 Inhibitor, Cox-2 Inhibitor Celebrex, Neither Have Tested, Long Enough Pfizer, Enough Pfizer Said, Conducting Longer Term, Longer Term Trials, Coronary Bypass Trials, Cleveland Clinic Foundation, Danger Signal Does, Really Safe Especially, Heart Risk That's, Open Question Topol, Question Topol Said, Topol Said Pfizer, Several Occasions Since, Stevens Johnson Syndrome, Allergic Reaction Often, Reaction Often Caused, Drug Symptoms Usually, Symptoms Usually Begin, Blisters Sometimes Become, Pfizer Admits, Cox-2 Drug, Drug Bextra, Heart Problems, Patients Taking, Taking Bextra, Same Class, Heart Attack, Sometimes Fatal, Fatal Skin, Skin Disorder, Disorder Called, Called Stevens-johnson, Stevens-johnson Syndrome, Being Seen, Seen More, More Often, Other Drugs, Treat Pain, Pain From, From Arthritis, Merck Co's, Co's Vioxx, Cox-2 Inhibitor, Recent Trial, Trial Showed, Showed Vioxx, Vioxx Doubled, Arthritis Patients, Vioxx Withdrawal, Cloud Over, Entire Class, Cox-2 Inhibitors, Inhibitors Which, Which Includes, Includes Bextra, Bextra Celebrex, Experimental Drug, Drug From, From Novartis, Called Prexige, Prexige However, However Pfizer, Pfizer Said, Clinical Data, Data Base, 8,000 Patients, Rheumatoid Arthritis, Increased Risk, Dangerous Heart, Heart Events, General Surgery, Surgery Setting, Doctors Said, Potential Risk, Pfizer's Other, Other Cox-2, Inhibitor Celebrex, Neither Have, Have Tested, Long Enough, Enough Pfizer, Conducting Longer, Longer Term, Term Trials, Coronary Bypass, Bypass Trials, Eric Topol, Cleveland Clinic, Clinic Foundation, Outspoken Critic, Vioxx Said, Finds Concerning, Heart Attacks, Danger Signal, Signal Does, Vioxx Celebrex, Appear Safer, Really Safe, Safe Especially, Heart Risk, Risk That's, Open Question, Question Topol, Topol Said, Said Pfizer, Several Occasions, Occasions Since, Stevens Johnson, Johnson Syndrome, Allergic Reaction, Reaction Often, Often Caused, Certain Types, Drug Symptoms, Symptoms Usually, Usually Begin, Lips Spreading, Throat Tongue, Other Parts, Blisters Sometimes, Sometimes Become