Biological,Hip,Joint,Prosthese health Biological Hip Joint Prostheses and Biomechanical Behavior o

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Introduction A highly interdisciplinary research group has been involved in the study of bone as a living material. The principal efforts have been devoted to mimic the bone characteristics and process of its formations and behavior under physiological loading (Apicella et al, 2010-2011, 2015; Gramanzini et al, 2016; Kummer, 1986; Perillo et al, 2010; Sorrentino et al, 2009, 2007).Advanced academic studies on biomechanics and biomimetic of implanted bones resulted from these investigations. This work project identifies a number of design criteria to foster their potential to enable new medical therapies contributing to customized health care, and to create and improve the technological basis for innovative prostheses design.The human femur is characterized by a specific internal structure (Oh and Harris, 1976; Gottesman and Hashin, 1980) that imparts to the bone a high capacity to withstand external stresses while optimizing its mass distribution and morphology (Ashman et al., 1984; Dalstyra et al., 1993). However, physiological bone mass loss progressively occurs at older age, reducing the its toughness and capability to dissipate the energy transmitted by external shock event, and this feature is the cause of most of the elder people pertrochanteric fractures along the plane indicated in figure 1.Aversa et al (2016) have successfully modeled this behavior. Pertrochanteric fractures need hip joint prosthesis application (Ashman and Rho, 1988, Burnstein et al., 1976, Carter and Hayes, 1977). The modification of the biomechanical behavior of aged or implanted bones can be correctly predicted using our previously developed biofidel Finite Element Modeling (FEM) (Apicella et al 2010, Aversa et al, 2009).Nonetheless, total hip replacements performed on patients younger than 65, and hence with a necessary longer expected durability of the orthopedic implant, cannot endure for more than 15 years. Nevertheless, this clinical scenario has been changing now. Several health care technological developments increased the life expectations. Moreover, the prognosis for physical trauma due to sports, improper and excessive exercise practice, or road crashes have been ameliorated. New design more long lasting and biomechanically compatible prostheses are then needed.The orthopedic prostheses used today are made of metal alloys, plastics and ceramics materials with well defined properties and characteristics.In particular, due to their high biocompatibility and high mechanical strength, the metal alloys commonly used are based on Titanium or Cobalt Chrome and they represent almost all of the prosthetic components that are in direct contact with the human bone since they can provide a good osteo-integration with the bone components.Implant failures are principally due to biomechanical incompatibility between the prosthesis and the bone, namely, the inadequate strength or mismatching of the rigidities between the bone and implant causes arise of discontinuities in the stress and strains distribution in the bone with respect to the biologically one.The current implant materials (metal and ceramic), which are more stiffer than bone, strongly alters the physiological bone stress distribution and prevents the needed stress being transferred to adjacent bone (Apicella et al, 2010, 2011, 2015), resulting in bone reabsorption near the implant and, thus, increasing the risk of implant loosening.In order to predict the structural alterations induced by the modification of the morphological and mechanical characteristic of the bone, faithful models of the femur have been developed (Aversa et al., 2016).The development of these bio-models has already enabled us to correctly predict physiological stress and strain distribution in the mandible and dental prostheses implant (Apicella et al 2010, Gramanzini et al 2016, Perillo et al 2010, Sorrentino et al 2009 and 2007).In the present work a femur FEM model, which has been developed in a previous work to correctly represent structural behavior of the femur head (Aversa et al., 2016) has been analyzed for the stress and strains distribution over the entire bone stem and head, and it has been modified to account for femur head resection and substitution with a Titanium hip joint prosthesis in the case of a pertrochanteric femur fracture (figure 1). A comparison between the biological stress and strain distributions in the femur models of the sound and prothesized femurs could help in the understanding of the correct design procedures needed to design new innovative biomimetic prostheses (Aversa et al., 2016 a-o, 2017 a-e; Mirsayar et al., 2017).  Materials and Methods Image Segmentation derived from CT has been performed using the Mimics software (Materialise, Belgium) to process a patient tomography. An accurate 3D solid model of the patient pelvis and femur anatomy, see Figure 2, has been derived by processing of CT data.New prostheses design through a combined use of Mimics and 3-Matic (Materialise, Belgium) software’s could be derived from the study of the biomechanics of these bone districts. Combined solid modeling and Finite Element analysis have been developed in a previous work by Aversa et al (2016).This methods simulates the structural morphology of the femur as it was already made for other complex bone structures that consider orientation and densities of the trabecular bone (Apicella et al 2010, 2011and 2015, Aversa et al 2016, Aversa et al 2009, Beaupre and al 1985, Reilly and Burstein 1974, Reilly and Burstein 1975, Huiskes et al 1987, Taylor et al 2007, Rohlmann et al 1982).Several recent investigations underlined the importance of the FEM analysis in clinical applications and for the development of new prosthetic systems (Mirsayar and Park 2016, Mazaheri et al 2016), and for the use of innovative materials and surface treatments (Kumar et al 2016).The methodological procedure is illustrated in the Figures from 3 to 6.The external geometry of femur and portion of the pelvis have been remodeled creating a 3D volume from the CT scans (Figure 3).The models were imported in the 3Matic software in order to create and optimize surface and solid meshing, which was needed to the preparation of the Finite element model and for the designation of material properties (Aversa et al., 2016).The results of tethraedric element material distribution are shown in fig.4.The same procedure has been applied to the preparation of the FEA model of the femur with the resection of the head (figure 5), which has been virtually related to the fracture plane reported in figure 1, and for the Titanium traditional hip-joint prosthesis (reported in the Left side of Figure 6).The model of the resected femur and of the Titanium prosthesis has been realized by definition of the 3D tethraedric mesh optimization of the distribution and size, as indicated in the right side of Fig. 5 and in fig. 6, respectively.The solid mesh elements of the resected femur have been associated to the bone densities such as measured by a Hounsfield (HU) scale, which compute the X-rays linear attenuation coefficients of in the tissues, by the Mimics software (lower part of fig. 5).The meshed solid models of the resected femur and of the Ti prosthesis were assembled accounting to the correct positioning of the implant using the Mimics software (figure 7).New remeshing of the tethraedric elements were run in 3Matic (figure 8) searching for the node congruency at the bone-implant interfaces, where the material definition has been made for the new finite elements configuration.The evaluation of mechanical properties has been done considering the cortical and trabecular bone mechanical characteristics.In the Hounsfield (HU) scale, the trabecular bone is in the range 100-300, while the cortical bone covers values from 200 up to about 2000, which corresponded in our bone systems to Elastic moduli ranging from 0,87 to 15.0 GPa. The fat value is about -110, the muscle about 40. Finally, the mechanical properties of the prosthesis Ti alloy are: elastic modulus equals to 124 GPa and Poisson ratio 0.3.FEM analysis: sound and prosthesis femurOn the basis of the 3D models of the sound femur, and the resected femurs implanted with a traditional rigid prosthesis, a structural evaluation under the same loading conditions has been developed and the results critically compared.The personal characteristic biometric parameters of the patient femur-hip system have been carried out before running the structural analysis.The 3Matic software has been used to identify the direction of the loading axis, the center of the proximal epiphysis head sphere, and the center of the joint epicondyle and mechanical axis of rotation of the knee.Namely, the following parameters have been measured: the mechanical axis between the centers of the proximal and distal epiphyses, the angle of 143.40 ° between the femoral neck and diaphysis axes, and the divergence of 36.65 ° between the neck axis with the axis of epicondyles.Finally (before running the FEM structural analyses) the physiological loads and constrains have been evaluated.As limiting bone load condition, the equilibrium monopodalic posture has been chosen where the gluteus muscular force balances the moment of body weight force. For a body weight of 100 Kg and accordingly to the previously defined biometric parameters, the gluteus muscular force applied to the great trochanter is about 1800 N and the reaction force at the joint 2740 N. (Kumar et al 2016, Annunziata et al. 2006).The equilibrium condition and femur-loading scheme are illustrated in figure 9.Reaction forces generated by the gluteus have been uniformly distributed over 100 nodes of great trochanter surface. The reaction forces acting at level of the femur joint are distributed on 50 nodes of the femur head (as indicated in the upper left of figure 9). Results and discussion  I This study defines a biofidel model to investigate the femur structural behavior. Von Mises strain criterion has been used to compare the stress distributions in sound and prosthesis femur under the previously defined loading conditions.This Von Mises is an energetic criterion that can better quantify the capability of the sound femur to withstand high loads (right part of Figure 9).Posteriorly, stress distribution confirms the presence of bending effects, with the highest values homogeneously distributed in the anatomical diaphysis regions (right hand side of figure 9) with a maximum of about 90 MPa.The same structural analysis has been carried out on the on the FE model of the prosthesized femur described in figures 7 and 8. The results of the analysis are compared in figure 10 to those evaluated for the sound femur.Figure 10 shows the significant alteration of the stress distribution in the sound femur (left hand side) and the resected femur with the rigid Ti prosthesis (right hand side).Compared to the physiological flexural stresses in the diaphysis of the sound femur, the prosthesized femur induces a concentration in the medial region while they are completely absent in the proximal end. This occurrence is referred as “stress shielding effect” and it is due to the high rigidity of the metal prosthesis stem that does not allow the physiological flexure of diaphysis.The absence of stress (and related strains state) could induce, over the time, significant bone structure modification (bone reabsorption).Bone modeling and remodeling processes, in fact, enable itself to grow, renew, and repair itself (Gottesman and Hashin, 1980; Huiskes et al., 1987; Taylor et al., 2007; Weinans et al., 1992). Mechanical adaptation of trabecular density and architecture could be explained in terms of mechano-sensory and signaling functions for the osteocytes (Mullender and Huiskes, 1995). Mechanic-regulation mechanism driving bone remodeling uses mechanical strain and micro-damage as the stimulus driving cellular responses and the consequent changes in the bone density and geometry. The absence or the modification of the biomechanical stimuli shown in figure 10 for the femur diaphysis after prosthesis implantation is then expected to lead, over the time, to a bone remodeling and reabsorption due to the absence of an adequate stress and strain state.  Conclusions  Results of our biofidel modeling of the sound and prosthesized bone would clarify the level of complexity needed when computing the strain state of a human femur through FEA when the stress and strain state has to be used to quantify the bone remodeling process.A faithful bone models allows the accurate choice of the femur locations where the hypothesis of isotropic conditions (diaphysis) can be made and the femur locations where the bone orthotropy hypothesis should be applied (proximal end epiphysis). The distribution of maximum strain is correctly described by our theoretical approach since can envisage the location of the pertrochanteric fracture. The model can be usefully applied in those cases where the strain distributions need to be evaluated in order to predict undesired bone remodeling processes.A further field of application of the product is surgical new prostheses design for orthopedic oncology to support and facilitate bone regeneration resulting in massive losses due to interventions of removal of both primitive and metastatic tumors.The prosthetic system could be redesigned to a better functional recovery by promoting bone recreation by bone growth stimulation while ensuring a good hold of the load.These improvements of the system biomimetic characteristics positively impact on the quality of life of the individual patient, which was already seriously compromised by the basic oncological pathology. References Annunziata M, Aversa R, Apicella A, Annunziata A, Apicella D, Buonaiuto C, Guida L, 2006, In vitro biological response to a light-cured composite when used for cementation of composite inlays, Dental Materials Volume 22, Issue 12, Pages 1081-1085Apicella D., Aversa, R., Ferro E., Ianniello D,  Apicella, A, 2010, The importance of cortical bone orthotropicity, maximum stiffness direction and thickness on the reliability of mandible numerical models,  Journal of Biomedical Materials Research - Part B Applied Biomaterials, Volume 93, Issue 1, April, Pages 150-163  (8): doi: 10.1002/jbm.b.31569Apicella D, Veltri M, Balleri P, Apicella A. and Ferrari M., 2011, Influence of abutment material on the fracture strength and failure modes of abutment-fixture assemblies when loaded in a bio-faithful simulation, Clinical Oral Implants Research, Volume 22, Issue 2, February, Pages 182-188: DOI: 10.1111/j.1600-0501.2010.01979.xApicella D, Aversa R, Tatullo M, Simeone M, Sayed S. 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