New,Direction,Chronic,Pain,Man health A New Direction in Chronic Pain Management
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Pharmaceutical companiesthat emphasis pain medications as one of their core areas of researchcontinually expend enormous amounts of their research and development budget ontrying to find new and unique pain medications. Some of these companies go so far as to merge with their competitionwhen their companies may advance in this endeavor. Others acquire other smallcompanies to accomplish this same goal. One of the major problemswith pain management is patient compliance. Often a pain medication, prescribedby a patient's pain management healthcare provider, is a perfect choice if thepatient would be more compliant with the pain medication administration. Now, companies such as Millennium out of SanDiego, California are working hard to demonstrate patient compliance, or lackthereof, by testing the patient's urine for the metabolites of a given painmedication. Each class of painmedication differs upon where, in the chain of physiologic reactions, does themedication act. Currently, the most usedpain medications are NSAIDs and opioids. The side effects of these twomedications include: nausea and vomiting, gastrointestinal bleeding andulceration, renal toxicity, constipation, cardiovascular events andhepatotoxicity. There arethree companies that have conducted studies of anti-nerve growth factor drugs(anti-NGF), that treat chronic pain: Pfizer was in a phase III clinical studyof its drug Tanezumab at the time that this article was originallydrafted. Since then Pfizer completed this study. Jansen also developed ananti-NGF pain medication they call Fulranumab. Regeneron Pharmaceuticalscurrently is completing a phase III clinical research study developing REGN472,its anti-NGF pain medication. These three companies allagree that there is a signal linking the use of anti-NGF drugs with thedeterioration of the joints. However,they say it's caused by patients that are found to use anti-NGF drugs at thesame time as taking nonsteroidalanti-inflammatory drugs (NSAIDs). Currently, the recommendation that is writtenin an obvious fashion in the information insert, is that it is contraindicatedfor the drug to be used along with a NSAID. Nerve Growth Factor worksby blocking a protein that causes an increased sensitivity to pain. As an accomplishedphysician and diplomat in pain management (DAAPM) and as a chronic painmanagement patient, I know the time has come for the development of a new classof pain medication with a much better side-effect profile. I feel that theopinions of healthcare providers who are, coincidentally, chronic painmanagement patients, should be given much more weight than they are currentlygiven to them.
New,Direction,Chronic,Pain,Man