Common,adverse,reaction,and,nu health Common adverse reaction and nursing of docetaxel
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Due to the drug's unique role in clinicalapplication, it needs to strengthen the observation and care while applying, asmuch as possible to reduce toxicity reaction. According to pharmaceutical raw materials suppliers,the main toxicity and nursing intervention measures of docetaxel are asfollows.Hematopoietic system reaction, bone marrowinhibition is the most common toxicity of docetaxel, with dosage and durationof treatment increased, blood toxicity exacerbations, and reversible. Generallyshow up after administration of 7days, performed for white cell andneutropenia, and thrombocytopenia.Nursing, during treatment should be closelymonitored blood, when the WBC < 1× 109/L, should implement protectiveisolation to patients. Keep the ward air clear, everyday have 2 times 40min UVirradiation, the ground with the 1:200 disinfection solution to wipe. alessening the visitation,prohibition of patients with known to infect visitors or staff contact,preventing cross infection. bThe medical staff should strictly abide by the principles of aseptictechnique operation careful washing hand before and after, contact touchpatients. cto informpatients pay attention to keep warm, prevent cold, keep the mouth, perianalskin clean. Observe whether the nasal, gums, skin bleeding, prolonged injectionsites pressing time. dif show up fever should pay attention to infection, should also payattention to a phenomenon that a few patients with less granulocyte count, whensevere infection, the body temperature does not rise.Digestive system reaction, docetaxel ongastrointestinal mucosa stimulation can lead to gastrointestinal disorders,usually occurs in the 1^ 8D of chemotherapy, manifestations of anorexia, nausea, vomiting,abdominal pain, diarrhea and others.Nursing, patients drinking a large numberof water during treatment, reduce the drugs on the gastrointestinal tractmucous membrane irritation. Encourage patients take easily digestible,high-protein, high vitamin and light diet, avoid spicy, fried stimulation food,have more meals a day but less food at each. Followed by doctors to useantiemetics before chemotherapy. After Patients with vomiting, gargle with warmwater, cleaning dirt, keep the mouth moist, clean, in order to promote theappetite. If frequent vomiting, should record the vomit nature, color, weight,preventing the electrolyte imbalance. To those eating less patients appropriaterehydration, enteral and parenteral nutrition support therapy if needed.Researches by docetaxelsupplier show that allergy is the most serious adverse reaction ofdocetaxel, manifestations of type I allergy. Often occur in 10min ofmedication, even can occur in the medication after 2^ 3min. The light appears palecomplexion, urticaria, serious person can appear dyspnea and shock.Nursing,`giving glucocorticoid before meditation, H2 receptor antagonists andantihistamines can reduce drug allergic reaction. aThe 10min before drug instillation shouldslowly, preferably using infusion pump infusion speed control in 10 ~ 15 dropsper minute. Close observation of patients consciousness, complexion, skincolor changes, if no adverse reactions can adjust the dropping speed in orderwithin the time prescribed infusion. binfusion during repeated inquiries patients with or without chockingsensations in chest, palpitation, dyspnea, skin itching and discomfort, everyhalf hour measuring vital signs. cIf emergence of flushing, itching skin, heart rate slightly faster, dontneed to stop the drugs, slow down the drop and close observation of changes inconditions. If show up chest tightness, dyspnea, generalized urticaria andother serious reaction, should immediately stop the chemotherapy and thecorresponding treatment. The use of disposable precise filtering transfusionapparatus can prevent allergic reaction.Source:http://www.cospcn.com
Common,adverse,reaction,and,nu