Resveratrol,and,cardiovascular health Resveratrol and cardiovascular disease
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Resveratrol used in vitro culturedhuman cells two weeks, the oxidation of manganese superoxide dismutase proteinlevels increased six-fold, the activity increased 14-fold, while the othermajor cellular antioxidants (glutathione peroxidase, catalase) found to beaffected or decrease in activity. Resveratrol by regulating manganesesuperoxide dismutase to part of extend the mitochondrial life, therebyprotecting mitochondrial away from the free radical damage, to complete thetask of its own capacity.In animal studies, resveratrol shows it canthrough a large number of mechanisms to protect the cardiovascular system,including inhibit the oxidation of low-density lipoprotein cholesterol(oxidation is the first step leading to atherosclerosis), protect and maintain theendothelial cells (artery wall cells) complete, promote small arteryvasodilation, inhibit platelet aggregation, as well as protection from ischemia- reperfusion injury (to reduce heart attack scale). Endothelial progenitorcells are adult stem cells produced by the bone marrow, through the bloodcirculation, then divided into the endothelial cells of repairing the arterywall. Diabetes, high blood pressure, high LDL cholesterol and cardiovasculardisease in patients with endothelial progenitor cells circulate volume decline.Resveratrol can increase the amount of endothelial progenitor cells, enhanceits functionality, what you need to do is suitable drinking the right amount ofred wine.According to several human epidemiologystudies, minor or moderate drinking red wine is related to reducecardiovascular disease, as well as the reduction of total mortality from allcauses have contact. Some studies have shown that drinking red wine can more reducethe incidence of cardiovascular disease and mortality than beer. A Dutch studyof middle-aged men show that, people who daily drink half a cup of red wine withthe lowest mortality, heart attack mortality lower 48%, while 40% reducedall-cause death compared with non-drinkers. In addition, the drinkers averagelife is 3.8 years longer than nondrinkers.In another study of pharmaceutical raw materials suppliers,30 patients with coronary heart disease in men taking a red grape polyphenol extract,their endothelium-dependent vasodilation improved, studies show that after 60minutes their arm rear of the brachial artery flow mediatedguide diastolicfunction get 73% improvement. This indicates that the red grape extract canalso be beneficial for people.Mice fed a high-fat and added resveratrol, therisk of death is 30% lower than high-fat diet mice fed only. Resveratrol withthe high-fat diet-induced 144 in155 set of genes sang a rival show. Blood glucose and insulin levels in ratsfed a high-fat diet have adverse change, and fed added the high-fat diet ofresveratrol animal the glucosyl level (and sometimes insulin levels) is closeto the normal diet of mice. Obese mice taking resveratrol also reduced theweight, and the ischemic function is more powerful, the ventricularfibrillation reduced 83% and 20% reduction in infarct size (the size of theorganization) of cardiac death. Here raises the question of whether resveratrolcan effectively prevent and treat diabetes?What most exciting is resveratrol has theeffectiveness of its anti-aging and slow down life, studies by resveratrolsupplier show that resveratrol extend the life span of yeast by 70%. Inaddition, resveratrol extended the life of short-lived fish up to 50%.Resveratrol also show the efficacy in extending the life of the insects. Thesestudies were used high doses of resveratrol, and through modest to moderateconsumption of red wine, what dose required to achieve the effect of prolonginglife remains to be determined.Source:http://www.cospcn.com
Resveratrol,and,cardiovascular