Lobaplatin,combined,with,docet health Lobaplatin combined with docetaxel treating breast cancer is
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According to pharmaceutical raw materials suppliers, docetaxelis one of the most effective drugs in the treatment of breast cancer, not onlyfor first-line treatment of breast cancer, the effective rate of 43.9% for thefirst-line treating advanced breast cancer failed single-agent, clinicalbenefit rate is 85.4%. Cisplatin as first-line treatment of metastatic breastcancer, single-agent response rate was 50%, the efficiency of cisplatin inlocally advanced breast cancer is greater than 80%, lobaplatin is the 3rdgeneration platinum anti-cancer drugs, anti-cancer activity is stronger, andthe toxicity is lighter.Docetaxel combined lobaplatin chemotherapyis not only have better efficacy for breast cancer also the toxicity can betolerated. But should be paying attention to the platelet inhibition, for theseemerged after chemotherapy in patients with thrombocytopenia, can consider theroutine after chemotherapy of platelet-colony stimulating factor to preventplatelets reducing.Drugs is used to treat a variety ofdiseases, but the adverse reaction is more or less harmful to humans normal tissues,adversely affected organs. Common adverse drug reactions including thedigestive system adverse reactions and liver toxicity, severe cases can lead togastrointestinal mucosal ulcers and lesions of the liver tissue and evennecrosis. For these conditions, taking some conditioning gastrointestinaltract, liver protection products can reduce the side effects of drugs such asthe Hericium polysaccharides, Coriolus versicolor polysaccharide and serves thepurpose of adjuvant therapy.Breast cancer is one of the most commonmalignancy in women, the world each year to check out the number of breastcancer is increasing every year. The latest research estimates that 2009 willhave more than 20 million women in the United States was diagnosed with breastcancer and 40,000 women died of breast cancer. Chinese breast cancer annualincidence rate is about 400,000, and increase 5% every year, has become one ofthe countries with the fastest growth rate of breast cancer incidence. At thesame time, the breast cancer with recurrence and multi-channel transfercharacteristics, is one of the cause of death in patients.Treatments of advanced breast cancer is incombination with chemotherapy, docetaxel is one of the most active drugs inbreast cancer chemotherapy. Docetaxel is belong to taxanes through theessentially "freeze" the internal skeleton of the cell inhibition oftumor cell differentiation microtubule cytoskeleton, microtubules in the cellcycle and timely assembly and spin-off phenomenon. Docetaxel promote theassembly of microtubules and prevents microtubule spin-off, leading to thearrangement of the microtubule bundle abnormal formation of the aster, spindleloss of normal function, leading to cell death. Studies by docetaxelmanufacturer show that in metastatic breast cancer, docetaxelmonotherapy in anthracycline treatment failure rate was 34% and 58%,combination chemotherapy effective rate is 60% to 80%.Epirubicin is the same isomers of adriamycin,the mechanism of action is directly embedded in the nuclear DNA of alkali oninterference of the transcription process, preventing the formation of themRNA, thus inhibiting DNA and RNA synthesis. Compared with doxorubicin, theefficacy is equal or slightly higher, but less toxic to the heart.Source:http://www.cospcn.com
Lobaplatin,combined,with,docet