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The irinotecanprice and the toxic side effects of anticancer drugs is a major factorlimiting the efficient use of irinotecan, because of serious side effectsaffecting the quality of life.According to pharmaceutical raw materials suppliers,Irinotecan is a DNA topoisomerase inhibitor, is the second-line drugs for thetreatment of colon and rectal cancer, and now scientists reported a mixed herb calledPHY906 in reducing theside effect of the gastrointestinal toxicity caused by irinotecan. Diarrhea andnausea are common side effects caused by irinotecan, taking this drug also showup ulcers within the intestinal bleeding, because it would lead to intestinalcell death and inflammation. However, the way to control these toxic sideeffects limit the play of its efficacy.PHY906 from an ancient Chinese medicineformulations for the treatment of nausea, vomiting and diarrhea, is composed of4 herbs, its quality by the stability control. Today, when PHY906 for patientstaking irinotecan, it can reduce the patients with diarrhea and vomiting. Inorder to study the PHY906 remission Irinotecan cause intestinal damage, theresearchers used a colorectal cancer model mice. 4 days of treatment withirinotecan conga PHY906 of such tumors in mice, found that PHY906 alone caninhibit tumor growth, but it can stimulate the irinotecan anti-tumor activity,and can ease this kinds of medication related weight loss. In addition, PHY906promote the recovery and regeneration of the intestinal cells by the injury ofirinotecan.Further studies have shown that, despitethe PHY906 could not prevent DNA damage caused by irinotecan in intestinalcells, but it can reduce the number of apoptosis, increased intestinal cellproliferation after irinotecan therapy. After irinotecan treatment, PHY906 canpromote intestinal progenitor-derived cells or the expression of stem cellmarkers, such as cell surface transmembrane glycoprotein CD44 leucinerepeat-rich G-protein coupled receptors (LGRs) and homologous chromosome 2(ASCL2).In the observed regeneration of intestinalcells, the signal path is also subjected to a stimulus, because of after takingirinotecan, PHY906 increased expression of key extracellular factor component,such as Wnt3, select FZD5 ( Frizzled 5) and low-density lipoprotein receptor-relatedprotein 5. The study about human embryonic liver cells also showed that PHY906treatment increased Wnt3Aactivity. Finally, the researchers also noted that, PHY906 inhibit severalsteps that irinotecan stimulate inflammation. PHY906 therapeutic blockingenteral neutrophil and macrophage infiltration, reduce the expression of proinflammatorycytokines such as tumor necrosis factor, etc.Therefore, despite of the PHY906 could notdirectly protect the intestinal system from the damage caused by chemotherapy,but it does through the promotion of the rebirth of the ancestral source cellsand inhibition of inflammation, intestinal cells to stimulate rehabilitation.This study emphasizes the value of traditional herbal treatment, explain thepossible therapeutic mechanism to regulate a variety of biological activity byherbal multi recipe ingredients, may be able to provide the efficacy ofconventional drugs can not be achieved.Source:http://www.cospcn.com Article Tags: Gastrointestinal Toxicity, Side Effects, Intestinal Cells
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