When,Acid,Reflux,Leads,Barrett health When Acid Reflux Leads to Barrett's Esophagus
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Most people will on occasion experience heartburn. It isn't apleasant feeling, but soon passes and happens only once in a while. Somepeople, however, are frequent sufferers of acid reflux. These people sufferweekly or even daily with the uncomfortable symptoms of acid reflux. When leftuntreated, acid reflux can become a serious condition often damaging the liningof the esophagus. In about 10% of the cases the lining of the esophagus becomesso damaged that it changes to resemble the lining of the stomach. Thiscondition is called Barrett's esophagus. It is considered a precursor toesophageal cancer and often goes on to become cancer. Although most people donot develop this disease, the number of people with it is on the increase. How Do You RecognizeBarrett's? Interestingly, Barrett's does not have any real symptoms of itsown. Acid reflux can cause uncomfortable burning sensations, sore throat,regurgitation of food, and hoarseness of the voice. Barrett's has nosignificant symptoms to add to the list. Many people are not aware that theyeven have it. People with Barrett's esophagus have an increased risk foresophageal cancer. If Barrett's esophagus has progressed to cancer of theesophagus, the symptoms can include difficulty swallowing or weight loss.Still, only a small number of people with Barrett's esophagus develop cancer.It can be detected and diagnosed with the used of endoscopy and a possiblebiopsy. Who Gets the Disease? Barrett's is more common in men, especially Caucasian men overfifty. It also tends to affect those who have suffered with acid reflux for along time or who began experiencing acid reflux at a very young age. Treatmentshould improve acid reflux symptoms and may keep Barrett's esophagus fromgetting worse. None of these treatments will reverse the changes that may leadto cancer. If you are experiencing acid reflux on a regular basis, it ishighly recommended that you seek the advice of your physician. There are anumber of medical and non-medical treatments that can be done to reduce acidreflux symptoms. These treatments not only make life more comfortable, but alsoprotect against further damage to your esophagus. Patients with Barrett'sesophagus typically need prescription medication to suppress the production ofstomach acid, such as generic Aciphex. Barrett esophagus, sometimes calledBarrett syndrome or columnar epithelium lined lower oesophagus (CELLO), refersto an abnormal change (metaplasia) in the cells of the inferior portion of theesophagus. A positive diagnosis generally requires observing specificmacroscopic and microscopic changes. The normal squamous epithelium lining ofthe esophagus is replaced by metaplastic columnar and goblet cells. Columnarepithelium refers to a cell type that is typically found in more distal partsof the gastrointestinal system. Only the presence of goblet cells equates adiagnosis of Barrett esophagus. The medical significance of Barrett esophagusis its strong association with esophageal adenocarcinoma, a particularly lethalcancer. The main cause of Barrett esophagus isthought to be an adaptation to chronic acid exposure from reflux esophagitis.In the last 4 years, the incidence of esophageal adenocarcinoma has beenincreasing in the Western world. Barrett esophagus is found in 515% ofpatients who seek medical care for heartburn (gastroesophageal reflux disease,GERD), although a large subgroup of patients with Barrett esophagus do not havesymptoms. It is considered to be a premalignant condition because it isassociated with an increased risk of esophageal cancer (more specifically,adenocarcinoma) of about 0.5% per patient-year. If the cancer develops, it isvery often deadly. Diagnosis of Barrett esophagus requires endoscopy (morespecifically, esophagogastroduodenoscopy, a procedure in which a fibre opticcable is inserted through the mouth to examine the esophagus, stomach, andduodenum) and biopsy. The cells of Barrett esophagus, after biopsy, areclassified into four general categories: non-dysplastic, low-grade dysplasia,high-grade dysplasia, and frank carcinoma. High-grade dysplasia and earlystages of adenocarcinoma can be treated by endoscopic resection and newendoscopic therapies such as radiofrequency ablation, whereas advanced stages(submucosal)are generally advised to undergo surgical treatment. Non-dysplasticand low-grade patients are generally advised to undergo annual observation withendoscopy, with radiofrequency ablation as a therapeutic option. In high-gradedysplasia, the risk of developing cancer might be at 10% per patient-year orgreater.
When,Acid,Reflux,Leads,Barrett