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Gettingchemotherapy before breast cancer surgery can mean the difference between amastectomy or a breast-conserving lumpectomy, experts say. And new researchshows that getting an MRI during the first round of chemo can help predictquickly if the cancer will respond to the treatment. Thus, increasing the favorableresults of breast cancer drugs like genericFemara Letrozole. "MRIworks better than clinical examination of the tumor, the standard way to assesshow well the chemotherapy is working," said researcher Dr. Nola Hylton, aprofessor of radiology and biomedical imaging at the University of California,San Francisco. "Whatwe are trying to do is fine-tune MRI so it can be a more sensitive measure ofwhether people are responding [to the chemo]," Hylton said. Aside fromchemo responses, to buy Femara online Canadawill never end up wasted. "Thisinitial finding said that after only one cycle of treatment, measuring thechange in the tumor volume [by MRI] was very predictive of whether that patientultimately had a good response to all the chemotherapy," Hylton said."Previousresearch has found that women who get chemotherapy before their surgery aremore likely to be able to have breast-conserving surgery than women given chemoafter their surgery." Thefindings don't surprise Dr. Joanne Mortimer, director of the Women's CancerProgram and co-director of the Breast Cancer Program at the City of HopeComprehensive Cancer Center in Duarte, Calif. "It'sa great idea," Mortimer said of performing the MRI sooner. "The MRIseems to be a more objective way [to gauge effectiveness of chemo]." Already,Mortimer said, "many doctors are ordering an MRI after chemotherapy is complete.The practice is to perform the MRI after the entire chemo session." "Whenyou give chemotherapy, the blood supply to the tumor changes," Mortimersaid. "TheMRI detects activity such as blood vessel formation in tumors, a marker ofwhether the tumor is responding to chemo," Hylton noted. Canada drugsreview can aid in improving positive results in various wayspossible. One such factor may be past hormone replacementtherapy, which was typically more widespread in higher income groups.The genes associated withhereditary breast-ovarian cancer syndromes usually increase the risk slightlyor moderately; the exception is women and men who are carriers of BRCAmutations. These people have a very high lifetime risk for breast and ovariancancer, depending on the portion of the proteins where the mutation occurs.Instead of a 12 percent lifetime risk of breast cancer, women with one of thesegenes have a risk of approximately 60 percent.In more recent years, research has indicated theimpact of diet and other behaviors on breast cancer. These additional riskfactors include a high-fat diet, alcohol intake, obesity, and environmentalfactors such as tobacco use, radiation, endocrine disruptors and shiftwork.Although the radiation from mammography is a low dose, the cumulative effectcan cause cancer. In addition to the risk factorsspecified above, demographic and medical risk factors include:· Personal history of breast cancer: A woman whohad breast cancer in one breast has an increased risk of getting a secondbreast cancer.· Family history: A woman's risk of breast canceris higher if her mother, sister, or daughter had breast cancer, the riskbecomes significant if at least two close relatives had breast or ovariancancer. The risk is higher if her family member got breast cancer before age 40.An Australian study found that having other relatives with breast cancer (ineither her mother's or father's family) may also increase a woman's risk ofbreast cancer and other forms of cancer, including brain and lung cancers.· Certain breast changes: Atypical hyperplasia andlobular carcinoma in situ found in benign breast conditions such as fibrocysticbreast changes are correlated with an increased breast cancer risk.
Canada,Drugs,Review,Breast,MRI