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There's more evidence that people with type 2 diabetes may have anincreased risk of bladder cancer, and taking the diabetes drug generic Actos cheap may raise that riskeven higher. "The evidence suggests that this drug is associated with about a22 percent increased risk of bladder cancer," said study senior authorJeffrey A. Johnson, the Canada Research Chair in Diabetes Health Outcomes atthe University of Alberta School of Public Health, in Canada. Johnson said it's not clear yet how Actos might raise the riskof bladder cancer, but he said some animal studies suggested that the drugcould cause crystals to form that irritate the bladder, which could potentiallyplay a role in the development of bladder cancer. Johnson added that it's important to keep in mind that bladder canceris a relatively rare cancer, and even with the increased risk, any one person'srisk of bladder cancer "is pretty small." People with type 2 diabetes have a 40 percent increased risk ofdeveloping bladder cancer, according to background information in the currentanalysis. This increased risk is believed to be associated with high levels ofinsulin found in people with type 2 diabetes. Insulin is a hormone that helpsthe body turn carbohydrates from food into sugar (glucose) that can be used forfuel. Insulin is also a growth hormone, and cancer cells have insulin receptorson them, which means they can use insulin to grow, according to Johnson. "The bladder cancer risk appears to be real, but is pretty small.If you're not at risk of bladder cancer in the first place, the benefits ofpioglitazone [Actos] may outweigh the potential risk," Johnson said. Commenting on the study findings, Dr. Joel Zonszein, director of theclinical diabetes center at Montefiore Medical Center in New York City, said:"Complications of diabetes can be very bad, and some patients do very wellon Actos." He added that he sometimes uses this medication in combination withother diabetes drugs. "Bladder cancer tends to be rare, but it's much morecommon in men and it's also more common in smokers, so I don't put elderly malesmokers on Actos. But, for other patients who have a low risk of bladdercancer, I may use Actos. We just have to be vigilant when we prescribemedications." Zonszein said it's also important to remember that people with type 2diabetes already have an elevated risk of bladder cancer, and they often don'tstart diabetes medications until they are much older, often obese and have hadthe disease for awhile, so "there may be a population bias" in thestudies. To buy Actos Canada has tobe checked and reviewed by doctors for safety. Diabetes mellitus, often simply referred to asdiabetes, is a group of metabolic diseases in which a person has high bloodsugar, either because the body does not produce enough insulin, or becausecells do not respond to the insulin that is produced. This high blood sugarproduces the classical symptoms of polyuria (frequent urination), polydipsia(increased thirst) and polyphagia (increased hunger).
Canada,Pharmacy,Review,Diabete