Hair,Loss,From,Steroids,Compre health Hair Loss From Steroids – A Comprehensive Look at the Proces

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@font-face { font-family: "Times";}@font-face { font-family: "-3 ";}@font-face { font-family: "Cambria Math";}@font-face { font-family: "Cambria";}p.MsoNormal, li.MsoNormal, div.MsoNormal { margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: Cambria; }.MsoChpDefault { font-family: Cambria; }div.WordSection1 { page: WordSection1; }Hair Loss From Steroids – A Comprehensive Look atthe Process and the Solutions.About 50% of the human male population are genetically susceptible to AlopeciaAndrogenetica, also known as Male Pattern Baldness. Although the exactcauses of male baldness are still unknown, most knowledgeable in this areawould agree that strong androgenic substances like DHT and testosterone play alarge part. If you are prone to MPB and are concerned about keeping your hair,then read on. There are some products that when used alone or especially incombination, can be very effective in halting or even reversing male hair loss.First, let's take a look at what is known about the causes of MPB. Testosteroneis converted to DHT by the 5AR enzyme, which in turn finds its way to your hairfollicles and causes them to fall out. The are a few theories on how thisoccurs. One suggests that DHT causes a progressive miniturization of theaffected hair follicles. Another says that DHT causes an autoimmune response,causing the body to actually attack the hair follicles as if they were aforeign body. This in turn causes an inflammatory response that causes the hairfollicles to shed.Either way, its a frustrating problem. A problem that can become greatlyaccelerated by the use of androgenic drugs, especially those with a highconversion rate to DHT. Testosterone, Anadrol, D-Bol...all of these end upincreasing the amounts of DHT in your system. Some, like test, convert throughthe 5AR enzyme. Anadrol, on the other hand, is not converted to DHT through the5AR method at all. 1-testosterone can also convert 'back' to DHT though theinfamous 'unknown pathway'...in any event higher levels of DHT end up at thescalp when you're using these substances. And, if you're prone, this couldspell rapid accelleration of genetic hair loss.Any androgenic hormone molecule binding to the receptors in your scalp couldadvance hair-loss in someone prone to MPB. When using steroids, especiallythose with strong receptor binding characteristics like 1-test or Trenbalone,the actual steroid itself could be a contributing factor to your hair loss, inaddition to any elevated levels of DHT in your system.So now we know that we need to prevent high amounts of androgen molecules fromaffecting hair follicles at the scalp. This could be done by using oralmedication, like: Finasteride Dose: 1-2mg /dayMean terminal half-life is approximately 5-6 hours in men 18-60 years of ageand 8 hours in men more than 70 years of age. There are two types of 5 alpha-reductase (AR), type I and type II, that act asa catalyst in converting testosterone into DHT. Propecia is a 5AR inhibitor,but only effectively inhibits Type II. It has no known effect on type I.Finasteride works by inhibiting the Type II 5alpha-reductase enzyme that isresponsible for converting testosterone to DHT. It is not clear as to whetheronly Type II 5AR is responsible for damage to hair follicles or if Type I isalso to blame. It is estimated that Propecia inhibits 70% serum DHT and 38%scalp DHT at the standard, recommended dosage of 1 mg per day. For peoplesuffering from natural hair loss or hair loss brought on by testosterone supplementation,oral 5AR inhibitors could work very well. 1Initially I was apprehensive about using finasteride to combat hairloss.However, not being satisfied with the rate of regrowth from topical-onlysolutions, I decided to start implementing oral Finasteride at ~1 mg/day. SinceIve started using it (along with LLLT therapy, see below), my hair reallystarted to thicken - even on the areas of my scalp that seemed to respond moreslowly to the topicals. I have no negative side effects at all.Read more about Finasteride pharmacology here:http://www.rxlist.com/cgi/generic3/propecia_cp.htmDutasteride Dose: .5mg /dayinvivo half life is approximately 5 WEEKS.Dutasteride ('Duta', 'Duagen'), also known as Avodart, is another oral5-alpha-reductase inhibitor. It is known to be more potent than Finasteride inthat it inhibits both type-I and type-II 5AR enzymes in the body. Dutasteridealso has a much longer half-life than Finasteride so any side effectsthat occur from use will be sustained for a much longer period of time. Some interesting facts about Dutasteride:The medication causes a significantdrop in both scalp and blood levels of DHT. Its effectiveness is felt to berelated to both of these factors. In patients taking finasteride 1-mg/day,serum DHT levels decreased by 68.4% and serum testosterone levels actuallyincreased by 9.1% but remained within the normal range. In patients takingdutasteride 0.5 mg/day serum DHT levels decreased by 85% in one week and 90% bytwo weeks. After one year of taking dutasteride 0.5mg/day serum DHT levelsdecreased by 94% and and testosterone levels increased by 19%, but thetestosterone levels remained within physiologic limits. Thyroid StimulatingHormone (TSH) levels increased 12.4% at 52 weeks and luteinizing hormone (LH)increased by 12% at 6 months and 19% at 12 months. We do not know whatthe long term consequences will be of the increase in testosterone, TSH, or LH.2However, a strong word of caution for those considering Dutasteride:The half life of dutasteride is 5 weeksat steady state. The average steady state concentration is 40ng/ml following0.5 mg/day for one year. Following daily dosing, dutasteride serum concentrationsachieve 65% of steady-state concentration after 1 month and approximately 90%after 3 months. Due to the long half-life dutasteride serum concentrationsremain detectable (greater than 0.1ng/ml) for up to 4 to 6 months afterdiscontinuation of treatment. Due to the long half-life side affects may last much longer. Therefore, werecommend you take Propecia for 6 months to one year prior to startingdutasteride. If you tolerate Propecia well, you may consider switching todutasteride at the end of your Propecia trial period. While higher dosages upto 2.5 mg of dutasteride have been shown to increase hair counts even greaterthan 0.5mg, this higher dosage has not been submitted to the FDA for theirapproval and no phase III human clinical trial at this dosage exist. 2Another important thing to keep in mind is that Dutasteride is metabolized bythe CYP3A4 enzyme in the liver. So are SERMs. I have no idea whether or notusing them both in conjunction could cause undue stress on the liver,as thereis plenty of CYP3A4 (its the CYP enzyme that's presnt in the largest amount inthe body) but its something to keep in mind until a clear answer can be found.In my own opinion, people should be weary of using Dutasteride to treat hairloss. Especially if you've never used an oral 5AR inhibitor before. Glaxo, thecompany that developed it, halted research on Dutasteride for a hair losstreatment for 'unknown reasons'. It probably isnt health related, because itsstill used as a BPH treatment. However, know that when you use Dutasteride totreat MPB, you are doing so at your own risk. It uncommonly long half life andlack of human trials would make me think twice about it, for sure.Note: oral 5AR blockers should never be used with Deca-Durabolin. It canactually promote hair loss in this situation. Deca reduces via 5AR to a lessandrogenic molecule called DHN (dihydronandrolone). If you inhibit 5AR while ona cycle of DecaDuraBolin, the compound could actually negatively impact yourexisting hair loss issues This brings us to the next weapon in the hair loss prevention arsenal:The Topicals Anti-Androgens There are a few chemicals out there which have been shown to inhibit androgenand DHT molecules at the scalp itself, without showing any systemic side effects.These are:Spironolactone Spironolactone was originally used as a "Potassium Sparing Diuretic",that has been used for many years to treat high blood pressure and fluidretention. Recently, it has also been used orally as an anti-androgen (it blocksthe androgen receptor itself). For hair loss prevention purposes, it has been found that a solution of Spiroin a 2-5% concentration can effectively block androgens (both DHT and others)from effecting the hair follicles at the scalp when applied topically. You canread more detailed info about some other uses of Spironolactone here:Keep in mind that although Spironolactone is generally thought to benon-systemic when applied to the scalp, a few users have reported low-androgenrelated symptoms when using topical Spiro. IMO, it should only be used on cycle,when a general androgen blocker is needed.Azelaic Acid Used as an acne medication, azelaic acid also has one important property whenapplied to the scalp:It inhibits DHT up to 100% at the area of application Taking all of theabove information into consideration, its obvious why we would want this aspart of a hair-loss prevention system.Nizoral Shampoo (2% Ketoconazole) When used EOD, Nizoral shampoo can help block the formation of DHT in thescalp. A special version of Nizoral shampoo , 'Regrowth Treatment Shampoo', isavailable that contains 3% salicylic acid . The salicylic acid helps strip deadlayers off the epidermis from the scalp, resulting in greater absorption of the2% Ketoconazole. Fluridil (Eucapil) I haven't learned much about this one yet. Thanks to LCSCULLA for bringing itto my attention. Supposedly has a longer half-life than Spiro. Cost might beprohibitive to some, but if it works as claimed it would be very valuable tothose trying to save their hair. Also a general anti-androgen.Ok, now we've covered treatments that can successfully block androgens and DHTat the scalp. For some, using these products alone might be enought to reverseMPB, prevent it during a cycle, etc. For those of you who are definitely prone to genetic MPB, you will needsomething to assist the stimulation of new hair growth:Hair Growth Stimulants After blocking androgens from affecting hair follicles, the next step is toattempt to promote hair regrowth.Minoxidil That's right, good ol' Rogaine. Well, the active ingredient in Rogaine, anyway.It was originally used as a high-blood pressure medication and vaso-dialator.Someone discovered that it increased hair growth on various parts of the bodywhen taken in high enough concentrations orally. I guess from there they triedapplying it to the scalp. Id love to be able to tell you exactly how Minoxidilworks to regrow hair, but no one knows. Knowing that it works and has nosystemic side effects is enough for now.A Note On Minoxidil UseOf course, there is a drawback with using Minoxidil to regrow your hair. You'llhave to use it daily, forever. Its been shown that a few months after Minoxidiluse has ceased, any hair regrown with it will start to shed. If your going tolose your hair anyway to genetic MPB, its a small trade off. 5 minutes 2x a dayand there's a good chance youll keep your hair, or at the very minimum slowdown the inevitable. In addition, in a small number of users, Minoxidil can cause some slight hairshedding when it is first applied. This is usually very minor and is actually agood indicator that Minoxidil is working for you. The hair that is shedeventually will grow back thicker, having been stimulated by the Minoxidil.Retin-A Retin-A, or Retonic Acid, can be used in combination with Minoxidil for asynergistic effect. Studies have shown that combined with minoxidil treatmentsit will regrow more hair faster than with minoxidil alone. It may increase theabsorption of Minoxidil through the skin, it also may have some hairregenerative properties. Again, not much is known about its method of action,only that it has positive results.Low Level Laser Therapy (LLLT)Initially, the notion of firing lasers at your scalp might seem like somethingout of StarTrek, not a real-world hair loss treatment. However, studies areshowing the biocell stimulation via laser light in a particular range canactually encourage the follicular cells to grow new hair. I wouldn’t have believedit, unless I'd experienced it for myself!to treat hair loss for years, swearing up and down that it had a positiveeffect on regrowth. I’m sure most people wrote them off as quack-jobs, until acompany called HairMax developed a personal version and started marketing itfor $700. I didnt hear about it until this DateLineNBC episode ran a segmentcalled 'The Follicle Five', that documented 5 guys trying to save their hairvia various methods:Oddly enough, the guy using the Laser Comb had some of the best results! Afterseeing that, I set off on some research and found that several people wereactually building their own 'Laser Brushes' and reported similar results. Afterreading through a bunch of threads, I came to the conclusion I could build a LLLTunit myself and I did, for $50. With 6 650nm 5mw Laser Diodes mounted in a niceboar's bristle brush, Ive been using it for the recommend 10minutes 2x per weekand honestly, my hair has never looked better.Keep in mind that I also started using Finasteride around the same time, butFinasteride isnt supposed to kick in for a couple months, and I noticed animprovement within 4 weeks using the laser brush. The 'Hair Loss Prevention Stack' So if you're truly worried about losing your hair, you have to take action assoon as possible. In this case especially, an ounce of prevention is worth apound of cure. If you're got some very mild thinning or if you're not thatsuseptable to androgenic hair loss, then Nizoral Shampoo EOD might be enough tostave off hair loss. For others that are sure they're going to lose their hair, its best to attackthe problem from all feasible angles as soon as possible. For this, there iswhat I like to call the 'Hair Loss Prevention Stack' My opinion is that your implementation of the various methods for combatinghair loss should follow a level-based approach. Start small and work up. Keepin mind that once you start using a treatment, you have to keep using it. Forever.Studies show that with nearly any hair loss prevention treatment, discontinuinguse will result in the person returning to his previous state of MPB within afew months. With this in mind, start with a solution that isnt too intrusive, and easy tomaintain.Ive come up with a couple 'stacks' that could be implemented in a progessivemanner. IE, if level 1 doesnt work, add level 2, etc.Check it out:Level 1:Regrowth Treatment Shampoo & LLLT Shampoo 3x per weekLLLT 10 minutes per session 2x per week Squeeze a quarter sized amount into your hand, and shampoo your hair. Messageit thourougly into your scalp, and leave in for about 5 minutes before rinsing.This shampoo dries your hair out, so its best to follow application with a goodconditioner.With the Laser Brush, hold it in place on your scalp for about 4 seconds at atime. Move it all around your head, trying to cover all the scalp evenly.Level 2:(Level 1 + ...)Nighttime application:Minoxidil 5%/Azelaic Acid 5%/Retin-A 2% Solution Applied ED, at night before bed. Sunlight breaks down Retin-A and can cause itto irritate the scalp, so its really only to be used at night time. Apply 1mlto the affected areas of the scalp and message into the skin. If your hair lossin generalized, part your hair in several areas and apply the solution directlyto the skin. Message into the skin. Daytime Application:Minoxidil 5%/Azelaic Acid 5% Solution Minoxidil/Azelaic Acid is meant to be applied 2x daily. You should use theMinoxidil w/Retin-A at night, and a solution containing Minoxidil and AzelaicAcid during the day. Try to keep the applications close to 12hrs apart if youcan. Apply to the scalp following the same method as outlined above.The nighttime application of the Minoxidil solution that includes Retin-A isoptional, and Ive found that it can irritate the scalp if used too often. Ifyou choose not to go with the Retin-A, just use standard Minox/AA solution 2xper day.Level 3:(Level 1 + Level 2 + ...)Oral Finasteride @ 1 - 2mg/dayYou can get a script from your doc for the Finasteride, but it is alsoavailable from online vendors as a 'research chemical'. I prefer to keep theorals for last, as I'd rather not put another chemical in my body if I didnthave to.I suppose you could keep going further here, and implement Dutasteride if theFinasteride wasnt working for you, but you get the idea. The above products, when used in combination in a consistent daily regimen,have restored my thinning head of hair to a decently thick mane in the past 24months. In fact, even on 200mg/1-test a day Ive had no shedding whatsoever. There are stronger concentrations of Minoxidil and Spiro solutions for thosethat arent responding to the 2% and 5% stuff. Always start with the lower dose,however. I have used Dr.Lee's 15% Minoxidil solution and I found it to be quiteeffective. As always, YMMV.A Final Note on Application Some complain that these products can make the hair look greasy. I find that ifI lightly towel-dry my hair, (not the scalp), my hair looks completely dry asif nothing were applied. Currently, I’m using the 'Level 3' solution and experiencing excellent results.It took ~2 years to work my way into using oral finasteride, however. After youstart a treatment, you really need to give it 2-3 months before you know if itsworking or not, sometimes longer. Some people have inhibitions about usingtopical treatments, but honestly, its not a big deal at all.Also, one thing I didn’t mention here is actual hair replacement surgery. Thisis a permanent solution and might be the only option for a non-responder to anyof the above treatments. There's tons of info about this out there on the web,I suggest you read up on it if you're interested. Credit to Big Vungra –moderator at Anabolic Minds. For more information click here for an article about androgen-related hair lossand hair transplants following ,-Will-Those-Hairs-Fall-Out-If-I-Continue-to-Use-Steroids?&id=6469962">hair loss from steroids.