Synchronized,Circadian,Rhythms health Synchronized Circadian Rhythms: Nature’s Cancer Fighter

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Timing is everything. Time is of the essence. Perfecttiming. Humanity’s captivation by temporal reality goes much deeper than theunifying framework of schedules, calendars, rituals and histories –it goes straight to our DNA. We live ina universe of cycles, nature’s clockwork, shaping and directing us since theliteral “dawn of time.” All life on earth is governed by a multitude of oscillatingrhythms – a perpetual ebb and flow of energy and movement. The rhythms of dayand night, the seasons and celestial motions, the rhythms of nature and oursocieties, all of these cyclical movements affect us at every layer of ourbeing. We have evolved in synchronicity with our rhythmic environment,anticipating and adapting to our surroundings for optimization of our internaland external resources. Our bodies follow innate biological clocks governingcellular, metabolic and developmental processes which fluctuate minute tominute, hour to hour, day to day, following 24-hour cycles, 2-day cycles,weekly cycles, monthly lunar cycles, seasonal cycles annual cycles, 7,8 12, and60 year cycles, life cycles, and more. The Harmony of TraditionalChinese MedicineTraditional Chinese Medicine (TCM) charts two hour dailyenergy cycles for each organ; weekly, monthly, yearly, and 7 and 8 year femaleand male developmental cycles; 12 and 60 years astrological cycles, along withother calendric patterns as they relate to our health and development. Based on this ebb and flow of energetic activity, the mostappropriate medical treatments can be administered at specific optimal times inorder to achieve maximum therapeutic effects. Much of TCM approach focuses onpromoting health on all levels by synchronizing a patient with the rhythms oftime, nature and the seasons. From a psycho-spiritual perspective, becomingfamiliar and in tune with these cycles serves as preparation for a harmonioustransition of our most important cycle, the cycle of birth, life and death.Chronotherapy: Fine TuningYour Health JourneyWestern medicine has also long theorized about our internalbiological clocks, known today as circadianoscillators or circadian clocks,and the physiological, metabolic and behavioral processes they rule over whichare known as circadian rhythms.Modern analysis of our circadian rhythms has given birth to a new therapeuticmodality known as chronotherapy, which, whether influenced by it or not,corresponds to much of TCM’s daily internal energy cycles. Emphasizing the mostbeneficial times of day to take certain medications such as statins andchemotherapy drugs, receive specific medical treatments such as radiationtherapy, and perform various functions , modern chronotherapy can be likened toa Western equivalent of TCMs ancient chronobiology protocols. Still in itsearly stages, Chronotherapy is gaining a reputation in conventional oncology,as new understandings in environmental influences on gene expression unravelsome of the mysteries of cellular cycles. In general, circadian rhythms relate to the 24 hour solarcycle and can be found in plants, animals, and even fungi and bacteria. Bodytemperature, blood pressure, muscular strength, levels of circulating hormones,neurotransmitters, and numerous other metabolic compounds and physiologicalprocesses follow the tides of circadian rhythm. Diseases have their own rhythms,too. For example, some breast cancers have been found to grow faster during theday than at night. Circadian Rhythms andYour HealthAccumulating evidence demonstrates that disruption ofcircadian rhythms is linked to the development of cancer, and in particular breast cancer. Theproper synchronization of biological rhythms is crucial for healthy cellcycles, DNA damage responses, and tumor suppression, among a multitude of otherfunctions, many of which are still not completely understood. However,scientists have discovered specific genes that control our circadian clocks,and several molecular components of the “clock machinery” have been found tointeract closely with regulators of the cell cycle. Thus, disruptions incircadian clock function can contribute to abnormal cellular metabolism and theproliferation of cancerous cells. A disrupted circadian clock has been called aGroup 2A carcinogen by scientists, placing it in the same carcinogenic class aslead compounds and diesel exhaust fumes. Recently, there have been studies linking shift work –working during the night hours – to breast and other hormone-related cancers.Along with frequent jet lag and other factors such as alcohol excess, shiftwork is a major disruptor of circadian rhythms, mostly due to the excessiveexposure to bright light during normal sleeping hours. Of all external cuesaffecting our circadian rhythms, light is the single most powerful influence.Prolonged exposure to bright light at night disrupts melatonin production, aserious affront to our health. Melatonin is perhaps the most importantendogenous component in the regulation of our circadian clocks and circadianrhythmic processes. Its production is highest during the dark hours of thenight when we can sleep in total darkness. Melatonin Helps resetYour Circadian ClockAs a supplement, melatonin plays in important role in cancertreatment and prevention, especially with breast cancer. In addition to havingpowerful immune modulating action, Melatonin has been shown to reduce estrogen receptor cells on ER+tumors, exhibit cytotoxic (tumor killing) activity, promote antioxidantactivity protecting DNA from oxidative stress, protect against side effects ofchemotherapy and radiation, and assist healing after surgery. Melatonin isconsidered a master hormone, influencing and regulating other hormones alongwith a multitude of biological processes, and it also exhibits neurotransmitteractivity, making it a very powerful molecule. People with diminished levels ofmelatonin are at a much higher risk for developing cancer, and in particular,hormone-related cancers. Supplementing with melatonin should be done with guidanceand supervision from your health care provider. Testing melatonin levels priorto supplementation will provide an accurate base line for appropriatetreatment. Cancer patients can take up to 20 mg before bed time, but for mostpeople, the dose is 0.5-3 mg nightly. Learn about other cancer-fightingsupplements by downloading a complimentary wellness guide at www.dreliaz.org/wellness-guide/mcp.Other Tips to RebalanceYour RhythmsAlong with melatonin supplementation, there are a number ofother ways to reset your circadian clocks. Following extremely consistentsleeping, eating and exercise habits at the appropriate times of day cangreatly synchronize your innate rhythms, benefitting your health far beyond manyother methods. Lastly, but perhaps most importantly, Traditional ChineseMedicine recommends very specific practices and therapies developed overmillennia, which help to harmonize people with the ebb and flow of the rhythmsof nature, the seasons, and the movements of celestial bodies. In ancient times, these natural cycles would serve toeffectively set and regulate our internal rhythm keepers. Ideally, we should notrequire elaborate scientific mechanisms to synchronize ourselves with nature.It is only now, engulfed in a world that in many ways functions counter-intuitivelyto our innate biology, that we have learned what it really means to be “out ofsync.” If we want to survive and thrive today, we need to take persistentmeasures to harmonize our internal and external symphonies. Learn more aboutnatural cancer prevention and treatment therapies by visiting www.dreliaz.org.