Gardner,syndrome,Detailed,Info health Gardner's syndrome Detailed Information
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Gardner's syndrome is characterized by the occurrence of many polyps in the colon together with tumors outside the colon. The further colonic tumors may consist of osteomas of the skull, thyroid cancer, epidermoid cysts, fibromas and sebaceous cysts. The numerous polyps in the colon predispose to the growth of colon cancer. The polyps most frequently start to form at teenage years. And colon cancer generally arises 10 to 15 years there after. The standard age of diagnosis of familial polyposis is 25 years of age, with cancers developing at age 20 to 30.However, cancers may occur anywhere from late infancy to the sixties. The reason of Gardner syndrome is inherited, with autosomal dominant bequest. A gene known as the APC (adenomatous polyposis coli) is nearby in over 80% of those with this disease. A person with the disease thus has a 50% chance of passing the gene on to each of their children. Most people who obtain the gene almost always manifest the disease although the expression of the disease can vary markedly from person to person. Gardner's syndrome has vanished as a separate entity. It has been merged into familial adenomatous polyposis (FAP).It is at this time considered basically a phenotypic variant of FAP. There are no specific symptoms. If the polyps become very large, they may cause intestinal bleeding, Intussusception, or Intestinal Blockage. People with this disease also have a superior risk of developing dermoid tumors, abnormalities of the retina, skin tumors, and bone tumors. Polyps are found in the stomach in over half of those affected with this disease. However, stomach polyps usually do not become cancerous. Treatment of the cutaneous manifestations of Gardner syndrome depends on the symptomatic or cosmetic nature and the location of the cysts. Treatment is related to that employed for ordinary cysts and engages excision or utilize of intralesional steroids if the cysts are inflamed. Cytotoxic chemotherapy is helpful in several cases refractory to more conservative treatment choices. Sigmoidoscopies will be wanted afterward to make sure no cancer develops in remaining parts of the intestine. This will be determined by one's primary care doctor and the surgeon who performed the surgery. Periodic upper endoscopy is utilized to make sure that cancer does not develop in the stomach or intestine, and will require to be continued even after the colon is removed. Article Tags: Gardner's Syndrome
Gardner,syndrome,Detailed,Info