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Few forms of kinin-mediated angioedema are attributed to hereditary or acquired C1-inhibitor deficiency.  Since the pathogenesis of the other forms are still not explained appropriately although they are not affected by histamines, they are considered in the C1 – Inhibitor deficiency. The C1 – Inhibitor is the activation controller for the plasma cascade systems that on activation generates inflammatory peptides. The drug class includes Berinert that is a purified form of C1 – INH derived plasma and is licensed for the treatment for acute Hereditary Angioedema. The class also includes Ruconest, Firazyr, Kalbitor and Cinryze. As per the data available with the United States of America US Hereditary Angioedema Association, 10759 people are suffering from HAE in the US, among which 3904 diagnosed with Type I and Type II HAE. The patient can get an accurate diagnosis via HAEA Angioedema Center, physician referral database, and medical advisory board doctors.  HAE diagnosis can be done via 3 specific blood test, namely, C1- inhibitor functional, C1- inhibitor quantitative (antigenic) and C4. This will not only ensure the positive result against HAE but will also ensure the doctor or physician to treat his patients in a better way. The global hereditary angioedema market in 2018 is accounted for more than US$ xx Bn and expected to reach a value of US$ XX Bn by 2027 with a significant CAGR of around 10.0 % over the forecast period of 2019-2027.Increasing per capita income is allowing the professionals and citizens to opt for better quality healthcare services. It allows the doctors or physicians to provide latest and expensive treatment to their patients; whereas, on the other hand, it facilitates improved versions of traditional treatments to the patients, thus, ensuring the increased life expectancy of the patients to some extent. It also regulates the cycle of routine body check-ups, ensuring the sound health of body and mind; in addition, it is also notifying the professionals about the actual health condition along with the might be upcoming problems or deteriorated health conditions. Elevating growth rate of economies. Furthermore, prophylaxis Therapy aids in the prevention and reduction of the frequency and severity of hereditary angioedema attacks. This therapy treats the HAE patients via 2 ways, accounting for long-term prophylaxis and short-term prophylaxis. Apart from this, there are 6 FDA approved products that are also used for preventing and treating the HAE attacks. The global hereditary angioedema market is categorized under various classes such as drug class, route of administration, distribution channel, and region. The drug class segment further divided into four other categories such as kallikrein inhibitor, selective bradykinin B2 receptor antagonist, C1 esterase inhibitor, and others. C1 esterase inhibitor segment is further divided into cinryze, berinert and ruconest. The route of administration segment further divided into three other categories such as intravenous, subcutaneous and oral. The distribution channel segment further divided into two other categories such as hospital, retail pharmaceutical.Based on the basis of Drug ClassC1 esterase inhibitorCinryzeBerinertRuconestSelective bradykinin B2 receptor antagonistKallikrein inhibitorOthersOn the basis of Route of AdministrationIntravenousSubcutaneousOralOn the basis of DistributionHospitalRetail PharmaceuticalHereditary Angioedema Market Regional SegmentationBased on region, the global hereditary angioedema market is segmented into six regions namely North America, Latin America, Asia Pacific, Europe, Middle East, and Africa. North America's hereditary angioedema market is expected to be the most dominating market throughout the forecast period due to the changing lifestyle of people, which often results in increased levels of anxiety and stress along with the adoption of hormone replacement therapy and ACE inhibitors. These symptoms are also responsible for triggering and increasing the incidence of HAE attacks. Hereditary Angioedema is a rare disease and yet it can mark its existence. As per a study conducted by the World Allergy Organization, a lump sum count of 40 million people are treated with ACE inhibitor annually. The increased prevalence of HAE attacks will result in the market growth of hereditary angioedema during the upcoming years.Hereditary Angioedema Market Competitive LandscapeThe global market for hereditary angioedema is dominated byBiocryst Pharmaceuticals, INC., CSL Limited, IBIO INC., IONIS Pharmaceutical, Pharming Group NV, Santarus, INC. and Shire PLC.