The,detoxification,role,glutat business, insurance The detoxification role of glutathione

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Glutathione is now been widely recognized as a whitening ingredients in theinternational market, mainly by blocking the of tyrosinase synthesis of melaninpathway to inhibit melanin production, so as to achieve the whitening effect.Glutathione’s whitening effect is significant, in recent years it has also beenwidely used as cosmetics material.Glutathione is a tripeptide combine ofglutamic acid, cysteine and glycine, mercapto group-containing,has detoxification of anti-oxidation and integration. The mercapto group on thecysteine glutathione active group (glutathione often abbreviated as G-SH),easy has integrated detoxification with certain drugs (such as paracetamol), atoxin (such as free radicals, iodoacetic acid, mustard, The combination oflead, mercury, arsenic and other heavy metals). Therefore glutathione (especiallyglutathione in liver cells) can be involved in the biotransformation, and thusthe machine body of harmful poisons into harmless substances, and excreted.Glutathione also helps to maintain normal immune system function.Glutathione not only removes the body offree radicals, but also can improve the body's immune system. The glutathione inmaintaining health, anti-aging, the efficacy of cells in slow elderly play betterthan the young. Glutathione also can protect the hemoglobin not to be oxidatedby oxidation hydroxide radicals and other oxidation so that it continued normalfunctioning of the ability to transport oxygen. Part of hemoglobin in red bloodcells under the action of hydrogen peroxide and other oxidants, the oxidationof ferrous iron to ferric iron to make hemoglobin into methemoglobin, losingthe aerobic capacity. Glutathione can directly in combination with an oxidizingagent such as hydrogen peroxide, to generate water and oxidized glutathione,but also be able to methemoglobin reduction is hemoglobin. The content of glutathionein human erythrocyte is high, it has important implications for protecting thered blood cell membrane protein thiol in a reduced state and preventinghemolytic.Glutathione to protect the enzyme moleculesin the-SH group, is beneficial for the enzyme activity play its role, and canrestore the activity of the-SH group which has been damaged by the enzymemolecule, to resume the enzyme activity. Glutathione can also inhibit ethanolagainst fatty liver. Glutathione a strong protective effect for the leukopeniasymptoms caused by radiation, radioactive drugs. And enter the body of toxiccompounds, heavy metal ions or carcinogen glutathione and promote excreted,play a role in detoxification.The glutathionemanufacturers remind that taking glutathione seldom show up nausea,vomiting and headache, rare rash. Glutathione couldn’t use in allergy, andshall not be used in combination with vitamin B12, menadione, CalciumPantothenate, orotic acid, anti-histamine preparations, sulfa drugs andtetracycline and so on.Source:http://www.cosprm.com preparý
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ýSCcapsaicin manufacturerextract capsaicin: (1) extract from natural Pepper system, early capsaicinextract from dry red pepper, extraction with an organic solvent after crushing,and concentrated to give a dark red to orange red oily liquid. Ether extractcolor darker than ethanol extraction of color, a little sticky. This oilcollectively called as capsicum oleoresin in the international market. Its mainingredient is capsaicin, dihydro-capsaicin, Are two dihydro capsaicin, highdihydropyridine capsaicin, capsanthin, carrot pigment, and citric acid,tartaric acid, malic acid, and other ingredients. Usually accounts for about 1%of the weight of dried fruit. The Oleoresin Capsicum through diethyl ether,dilute ethanol, and an aqueous alkaline solution, or concentrated furtherextracted with petroleum ether, dichloroethane, etc. solvent, crystallized frompetroleum ether or n-oxide crystallization can be obtained crude capsaicin.Using gas chromatographic to analysis the crude capsaicin crystallinecomponent. Which accounted for 76% -96% capsaicin and dihydro pepper alkalicontent. The researchers used high-concentration ethanol extraction capsanthin,a low concentration of ethanol extract of capsaicin. Capsaicin of 6% to 8% and3% to 4% of capsanthin were extracted from the dried chili. First they use alow concentration of ethanol extracted from dried chili powder, pepperoleoresin capsaicin solution. The capsaicin solution was concentrated to givethe crude product of capsaicin. The process is simple, low cost, the use ofacetone, petroleum ether, 95% Ethanol capsicum oleoresin and the solvent as aresult, and then ether to give the crude crystalline capsaicin, and purified bycolumn chromatography on silica gel to give the pure product of capsaicin. Wasalso a direct high yield capsaicin extracted from fresh green chili. The freshchilli powder pulverized frozen, and dried with acetone, ether, aqueousmethanol, and an aqueous alkaline solution extract capsicum oleoresin, get acapsaicin crude in ether. Get pure capsaicin from Petroleum ether andrecrystallized. Yield was 1.12% of the dried chili. (2) Preparation from biologicalcell cultivating. The capsaicin research in many countries was no longersatisfied with the system from natural pepper capsaicin, but use of abiological cell technology to produce more and faster capsaicin. Researchersfrom natural pepper meat-like body, the cells will be taken by its embedding andfixed, was suspended in 5 liters of an aqueous culture liquid, after 32 daysthe pepper alkali content is achieve a high degree, if extend the incubationtime, chili alkali content will increase. (3) chemical synthesis methods take highpurity capsaicin is very difficult due to the natural pepper have manyanalogues of capsaicin. People trying to get a successful synthetic capsaicin.Researchers use triphenylphosphine and 6 - bromo-acid as raw materials. Throughfour-step reaction, the synthesis of a sample of the extract obtained isidentical to the pure capsaicin. The total yield is 26.6%.Source:http://www.cospcn.com